Ask your pharmacist any questions you have about refilling your prescription. Limited data from animal studies indicate no adverse effects on the pregnancy or the unborn child. It will not treat an angina attack that has already begun. Both versions of isosorbide mononitrate (Monoket) contain the same active ingredient. Seek alternatives to the CYP3A4 substrate when possible. Always consult your healthcare provider. The list below does not include all possible drug interactions with isosorbide mononitrate (Monoket). A healthcare professional should be consulted before taking any drug, changing any diet or commencing or discontinuing any course of treatment. Information is for End User's use only and may not be sold, redistributed or otherwise used for commercial purposes. The .gov means its official. HHS Vulnerability Disclosure, Help By signing up, I agree to GoodRx's Terms and Privacy Policy, and to receive marketing messages from GoodRx. Commonly reported side effects include: See also: isosorbide mononitrate side effects in more detail. The information on this page is written and peer reviewed by qualified clinicians. What You Need to Know, Angina (a specific type of chest pain) caused by heart disease. If tolerance is suspected during the use of transdermal patches they should be left off for 8-12 hours (usually overnight) in each 24 hours; in the case of modified-release tablets of isosorbide dinitrate (and . Do not keep out-of-date or unwanted medicines. What special precautions should I follow? WebMD does not provide medical advice, diagnosis or treatment. Valerian: A safe and effective herbal sleep aid? Journal of the American College of Cardiology. This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. Alcohol will increase the risk of you experiencing side-effects such as feeling dizzy and light-headed. Use of herbal products and potential interactions in patients with cardiovascular diseases. Minimally clinically significant. If you are having an operation or dental treatment, please remember to tell the person carrying out the treatment which medicines you are taking. This side-effect usually disappears after a few days, Do not drive and do not use tools or machines while affected, If either of these becomes troublesome, speak with your doctor. Aspirin has an average rating of 2006 Apr;95(4):217-23. doi: 10.1007/s00392-006-0367-x. Results of our real-world drug study have been referenced on 600+ medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Call your doctor for medical advice about side effects. 72% of reviewers reported a positive effect, while 12% reported a negative effect. Review/update the https://naturalmedicines.therapeuticresearch.com. It has a very short duration of action and may not be suitable for some people. 1994 Jan;15(1):108-13. doi: 10.1093/oxfordjournals.eurheartj.a060361. Your doctor may recommend treating headaches with an over-the-counter pain reliever (such as acetaminophen, aspirin). Tell your pharmacist what products you are using, and ask how to use them safely (especially cough-and-cold products, diet aids, or NSAIDs such as ibuprofen/naproxen). Does isosorbide mononitrate (Monoket) affect your kidneys? Accessed Sept. 7, 2022. Let your provider know if they are excessive. Many herbal supplements can interact with prescription drugs. Call your doctor if you have any unusual problems while you are taking this medication. This medicine is a white, round, scored, tablet imprinted with "KU 107" and "20". For these reasons, before you start taking isosorbide mononitrate it is important that your doctor knows: Along with their useful effects, most medicines can cause unwanted side-effects although not everyone experiences them. prevention of anginal chest pain associated with coronary artery disease, prevent bleeding varicose vein in the esophagus. Conclusions: With any medication, there are risks and benefits. Alcohol, including beer, wine, and spirits, does raise your blood pressure if its consumed in excess. Mayo Clinic does not endorse companies or products. Additionally, TRUVEN HEALTH MAKES NO REPRESENTATION OR WARRANTIES AS TO THE OPINIONS OR OTHER SERVICE OR DATA YOU MAY ACCESS, DOWNLOAD OR USE AS A RESULT OF USE OF THE THOMSON REUTERS HEALTHCARE PRODUCTS. Who should not take Isosorbide Mononitrate? This should pass after a few days. Isosorbide mononitrate (Monoket) may interact with certain medications or supplements. The two dosage regimens were equally efficient for the relief of angina pectoris without development of tolerance. What special dietary instructions should I follow? This list covers only some interactions. Highly clinically significant. Aspirin relieves pain and inflammation and helps to thin the blood. If you notice any other effects, check with your healthcare professional.Call your doctor for medical advice about side effects. Background: Nitrates, although important for the management of angina pectoris, cause significant headache in many patients. Isosorbide mononitrate (Monoket) can cause some serious health issues. In a randomized, double-blind, crossover study, 89 patients with stable angina pectoris were studied to compare two different dosage strategies of isosorbide-5-mononitrate (5-ISMN). We comply with the HONcode standard for trustworthy health information. daily and increasing to 40 mg three times daily as necessary, given at 8 AM, 1 PM, and 6 PM), isosorbide mononitrate (starting at 30 mg/day in the morning and increasing to 120 mg/day as necessary), or a transdermal. Classes: Nitrates, Angina Print Dosing & Uses AdultPediatricGeriatric Dosage Forms & Strengths tablet 10mg 20mg. Some brands of isosorbide mononitrate tablets should be taken two or three times a day. Instead, the best way to dispose of your medication is through a medicine take-back program. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. In case of overdose, call the poison control helpline at 1-800-222-1222. Isosorbide can only be used to prevent angina; it cannot be used to treat an episode of angina once it has begun. Take this medication by mouth as directed by your doctor, usually twice a day. If concomitant therapy cannot be avoided, monitor clinical effects of the . Your doctor will schedule your doses so that there is a period of time every day when you are not exposed to isosorbide. Even if the medication is working, you may experience some unwanted side effects. This medicine is for you. Careers. This activity describes the indications, action, and contraindications for isosorbide as a valuable agent in treating angina pectoris due to coronary artery disease, heart failure with reduced . Headache is often a sign that this medication is working. Limit alcoholic beverages. 2005 - 2023 WebMD LLC. Methods: In a randomized, double-blind, crossover study, 89 patients with stable angina pectoris were studied to compare two different dosage strategies of isosorbide-5-mononitrate (5-ISMN). FOIA Your doctor may decide not to treat you with this medication or change some of the other medicines you take. The information eHealthMe analyzes includes: Phase IV trials are used to detect adverse drug outcomes and monitor drug effectiveness in the real world. A randomized, double-blind, cross-over study. Store in a cool, dry place, away from direct heat and light. You will find a full list in the manufacturer's information leaflet supplied with your medicine. We study 23,548 Isosorbide mononitrate users. This does not necessarily mean no interactions exist. Meinertz T, Lehmacher W; Trapidil/ISDN Study Group. Store at room temperature away from light and moisture. You can develop a tolerance to isosorbide mononitrate (Monoket) over time, which means the dose you've been taking doesn't work as well. Accessed Sept. 7, 2022. Isosorbide mononitrate dilates (widens) blood vessels, making it easier for blood to flow through them and easier for the heart to pump.Isosorbide mononitrate is used to prevent angina attacks ( chest pain ). Although not all of these side effects may occur, if they do occur they may need medical attention. This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. There may be variations in CSA schedules between individual states. This medicine is available only with your doctor's prescription. It is not suitable to take to treat an angina attack - you should always carry with you a short-acting nitrate, such as glyceryl trinitrate (GTN), for if you get angina pain. Do not stop taking it without consulting your doctor. Some of the common derivatives include isosorbide dinitrate and isosorbide mononitrate, which are . Portions of this document last updated: Feb. 01, 2023. Herbal supplements are natural, so they must be safe, right? government site. MeSH Can isosorbide mononitrate cause problems? Higher than recommend dosage of sublingual isosorbide dinitrate for treating angina pectoris: a case report and review of the literature. Does isosorbide mononitrate (Monoket) lower blood pressure? Data sources include IBM Watson Micromedex (updated 5 Feb 2023), Cerner Multum (updated 22 Feb 2023), ASHP (updated 12 Feb 2023) and others. Accessed Sept. 7, 2022. May also be prescribed off label for Esophageal Spasm. Which drugs or supplements interact with isosorbide mononitrate? Be sure to mention any of the following: aspirin; beta blockers such as atenolol (Tenormin, Tenoretic), carteolol , labetalol (Trandate), metoprolol (Lopressor, Toprol-XL, in Dutoprol, in Lopressor HCT), nadolol (Corgard, in Corzide), propranolol (Hemangeol, Inderal, Innopran), sotalol (Betapace, Sorine, Sotylize), and timolol; calcium channel blockers such as amlodipine (Norvasc, in Amturnide, in Tekamlo), diltiazem (Cardizem, Cartia, Dilt-CD, others), felodipine (Plendil), isradipine, nifedipine (Adalat CC, Afeditab, Procardia), and verapamil (Calan, Covera, Verelan); ergot-type medications such as bromocriptine (Cycloset, Parlodel), cabergoline, dihydroergotamine (D.H.E. Nitroglycerin works very quickly to widen your blood vessels and help your heart pump blood during a heart attack. Accessed Sept. 7, 2022. We study millions of patients and 5,000 more each day. information is beneficial, we may combine your email and website usage information with you should know that you may experience headaches every day during your treatment with isosorbide. Integrative medicine (complementary and alternative medicine). Mayo Clinic. https://www.uptodate.com/contents/search. The American Society of Health-System Pharmacists, 4500 East-West Highway, Suite 900, Bethesda, Maryland. American Society of Health-System Pharmacists, Inc. Disclaimer, U.S. Department of Health and Human Services. Read our editorial policy. 1998-2023 Mayo Foundation for Medical Education and Research (MFMER). The tablet usually is taken two or three times daily. There are no data on passage of isosorbide mononitrate in human milk, but some excretion seems likely. Many people using this medication do not have serious side effects. Talk to your provider if you notice your chest pain starts to get worse. Does Isosorbide Mononitrate interact with other drugs you are taking? Accessed Sept. 7, 2022. It is best not to drink alcohol while you are on isosorbide mononitrate. In Canada - Call your doctor for medical advice about side effects. Mehta D. Herbal & dietary supplements. Includes Isosorbide Mononitrate indications, dosage/administration, pharmacology, mechanism/onset/duration of action, half-life, dosage forms, interactions, warnings, adverse reactions, off-label uses and more. Now, youll enjoy a streamlined experience created specifically for healthcare providers. No you may not. amlodipine, lisinopril, aspirin, metoprolol, furosemide, carvedilol, propranolol, spironolactone, atenolol, diltiazem. Contact your provider right away if you feel as if you are going to pass out and are experiencing an irregular heartbeat, nausea, vomiting, changes in vision, more sweating, or cold and clammy skin. Registered number: 10004395 Registered office: Fulford Grange, Micklefield Lane, Rawdon, Leeds, LS19 6BA. Talk to your provider if you continue to feel dizzy or have a fast heart rate a week after starting isosorbide mononitrate (Monoket). [2] It can be used both to treat and to prevent heart-related chest pain; however, it is generally less preferred than beta blockers or calcium channel blockers. Nitroglycerin has an average rating of When used regularly on a long-term basis, this helps prevent angina attacks from occurring. Laboratory and/or medical tests (such as blood pressure) should be performed periodically to monitor your progress or check for side effects. Are you looking for information on isosorbide dinitrate (Isordil) instead? Isosorbide mononitrate is used to prevent chest pain ( angina) in patients with a certain heart condition ( coronary artery disease ). Prescribed for Angina, Heart Failure, Angina Pectoris Prophylaxis. Do not share this medication with others. Prescription and OTC Aspirin relieves pain and inflammation and helps to thin the blood. Hawthorn. include protected health information. Take the missed dose as soon as you remember it. from the best health experts in the business. Isosorbide mononitrate dilates (widens) blood vessels, making it easier for blood to flow through them and easier for the heart to pump.Isosorbide mononitrate is used to prevent angina attacks (chest pain). Store it at room temperature and away from excess heat and moisture (not in the bathroom). Alcohol or marijuana (cannabis) can make you more dizzy. The IR version can help treat and prevent angina. It's usually not a problem for most people unless you drink alcohol or take other medications that can also lower your blood pressure. Bookshelf 1998 Oct;61(10):577-83. Changing positions slowly can help lessen dizziness. Subscribe to Drugs.com newsletters for the latest medication news, new drug approvals, alerts and updates. Natural Medicines. flushing - try to cut down on coffee, tea and alcohol because they can make flushing worse. Isosorbide mononitrate vs. Amlodipine besylate, Isosorbide mononitrate vs. Bisoprolol fumarate, Isosorbide mononitrate vs. Diltiazem hydrochloride, Isosorbide mononitrate vs. Isosorbide dinitrate, Isosorbide mononitrate vs. Metoprolol succinate, Isosorbide mononitrate vs. Metoprolol tartrate, Isosorbide mononitrate vs. Nitrolingual pumpspray, Isosorbide mononitrate and Aspirin (7,880 reports), Isosorbide mononitrate and Furosemide (6,020 reports), Isosorbide mononitrate and Amlodipine (3,554 reports), Isosorbide mononitrate and Simvastatin (3,508 reports), Isosorbide mononitrate and Omeprazole (3,422 reports), Isosorbide mononitrate and Lisinopril (3,099 reports), Isosorbide mononitrate and Metformin (2,822 reports), Isosorbide mononitrate and Carvedilol (2,589 reports), Isosorbide mononitrate and Clopidogrel (2,524 reports), Isosorbide mononitrate and Acetylsalicylic acid (2,355 reports). Of the total drug interactions, Accessed Sept. 7, 2022. 7 disease interactions. Does Alcohol Raise Your Blood Pressure? It took me a few weeks to adapt to it, but the effect on preventing chest pain was dramatic. All rights reserved. The easiest way to lookup drug information, identify pills, check interactions and set up your own personal medication records. Do not drink alcohol while taking View side-by-side comparisons of medication uses, ratings, cost, side effects and interactions. Natural Medicines. This content does not have an English version. There are 195 drugs known to interact with 2023 Lybrate, Inc. All rights reserved. See also: nitroglycerin side effects in more detail. 2023 eHealthMe.com. Can cause dizziness, especially when you change positions, Interacts with erectile dysfunction medications. Please enable it to take advantage of the complete set of features! Mayo Clinic; 2021. Swallow the extended-release tablets or capsules whole; do not crush, chew, or divide them. Background: This makes it easier for your heart to pump, relieving heart-related chest pain. It also may keep some medicines from working as well as they should, such as: If your health care provider tells you it's OK to use an herbal supplement along with medicine, be careful. Enter your medication into the WebMD interaction checker, Smart Grocery Shopping When You Have Diabetes, Surprising Things You Didn't Know About Dogs and Cats, Fitness vs. AskMayoExpert. Accessed Sept. 7, 2022. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. it is a safe and effective alternative; the choice between beta blockers and calcium channel blockers depends . Headache and weakness of left side (both arm and leg) may suggest a brain pathology. I took this for 4 days, and my headaches were unbearable. Change positions slowly until your body is used to the medication. Natural Medicines. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. Talk to your pharmacist for more details. It will not treat an angina attack that has already begun. The Swedish Multicentre Group. The https:// ensures that you are connecting to the Avoid combinations; the risk of the interaction outweighs the benefit. In the US - Call your doctor for medical advice about side effects. Isosorbide dinitrate dose 30-120 mg daily in divided doses. The information contained in the Truven Health Micromedex products as delivered by GoodRx is intended as an educational aid only. Always let your doctor and pharmacist know about any other medications or supplements (including prescribed and over-the-counter medications, vitamins, and dietary or herbal supplements) that you are currently taking. You need to take it every day in order for it to work. Isosorbide mononitrate is used to prevent chest pain (angina) in patients with a certain heart condition (coronary artery disease). While both isosorbide mononitrate (Monoket) and nitroglycerin (Nitrostat) are both nitrate vasodilators, they are not the same medication. You can consult me online for homeopathic treatment. As precautionary measure, it is preferable to avoid the use of isosorbide mononitrate during pregnancy. Healthcare data is obtained from a number of sources including the Food and Drug Administration (FDA). The effects of this exposure on a nursing infant are unknown. If the victim has collapsed, had a seizure, has trouble breathing, or can't be awakened, immediately call emergency services at 911. Overview of herbal medicines and dietary supplements. tell your doctor if you are pregnant, plan to become pregnant, or are breast-feeding. The most common side-effect is headache. Isosorbide is in a class of medications called vasodilators. This chest pain can feel more intense or painful than it was before you began taking isosorbide mononitrate (Monoket). Your health care provider and pharmacist can help you stay away from unsafe interactions. Talk to your pharmacist or contact your local garbage/recycling department to learn about take-back programs in your community. My blood pressure, cholesterol and pulse are all normal and I have no chest pains, shortness of breath or other heart problem symptoms. Take your next dose at the regular time. Our original studies have been referenced on 600+ medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Take them to your local pharmacy which will dispose of them for you. Mayo Clinic Graduate School of Biomedical Sciences, Mayo Clinic School of Continuous Professional Development, Mayo Clinic School of Graduate Medical Education, Alternative cancer treatments: 11 options to consider. As precautionary measure, breast-feeding should be discontinued during treatment with isosorbide mononitrate. [2] It is taken by mouth. Sign up for free, and stay up to date on research advancements, health tips and current health topics, like COVID-19, plus expertise on managing health. Talk to your doctor or pharmacist about lifestyle changes that might benefit you. It is usually caused by narrowing of your coronary arteries due to a build-up of a fatty substance called atheroma. Any use of this site constitutes your agreement to the Terms and Conditions and Privacy Policy linked below. Advertising revenue supports our not-for-profit mission. Elantan, Imdur, Isotard, Monomax, Tardisc, Xismox. All rights reserved. This is so your doctor can check on your progress. About one-half of adults in the United States say they have used one or more supplements in the past 30 days. Lifestyle changes such as dietary changes, exercise, and not smoking may help this drug work better. For instance, many herbal supplements that are used often interact with the blood thinner warfarin (Jantoven). The herb licorice may lower warfarin levels and can add to digoxin's effects. Prescription only Prescribed for Angina, Heart Failure, Angina Pectoris Prophylaxis. It can cause your blood pressure to become dangerously low. Check with your doctor immediately if any of the following side effects occur: burning, crawling, itching, numbness, prickling, "pins and needles", or tingling feelings, dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position, fast, slow, irregular, pounding, or racing heartbeat or pulse, itching, pain, redness, or swelling on the leg, numbness or tingling in the hands, feet, or lips, pain or discomfort in the arms, jaw, back, or neck, pain, tension, and weakness upon walking that subsides during periods of rest, shakiness in the legs, arms, hands, or feet, swelling of the face, fingers, feet, or lower legs, trembling or shaking of the hands or feet, vomiting of blood or material that looks like coffee grounds, Bluish-colored lips, fingernails, or palms.

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